In today's Nature (2006, Vol 441, Issue 18, p 358) there is a report of a novel antibiotic with activity against MRSA and vancomycin-resistant enterococci.
However, as far as I can see, it's a real monster of a structure to synthesise, with two quaternary stereocentres and a polycylic core with no handles for stereocontrol.
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1 comment:
I thought I'd posted a picture of the structure, but it didn't seem to work - you'll just have to look up the article, or take my word that it's a synthetic challenge.
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